Thorne C, Urowitz M B
Ann Rheum Dis. 1982 Oct;41(5):486-9. doi: 10.1136/ard.41.5.486.
Felty's syndrome has again been shown to be a severe form of systemic rheumatoid disease characterised by severe joint involvement, many extra-articular features, and a high incidence of infection. In addition we have shown that splenectomy was not protective for infections and in fact may on occasion contributed to infection. Furthermore, although most patients had an increase in white blood cell count after splenectomy, 50% of patients without splenectomy showed a similar increase in white blood cell counts at follow-up. Mortality in Felty's syndrome was high, with infection being the main cause of death.
费尔蒂综合征再次被证明是一种严重的全身性类风湿疾病，其特征为严重的关节受累、许多关节外表现以及高感染发生率。此外，我们已经表明脾切除术对感染并无保护作用，实际上有时可能会导致感染。而且，尽管大多数患者在脾切除术后白细胞计数有所增加，但50%未进行脾切除术的患者在随访时白细胞计数也有类似增加。费尔蒂综合征的死亡率很高，感染是主要死因。
