Gürtler R, Matthes M L, Tanneberger S
Arch Geschwulstforsch. 1982 May;52(3):231-40.
In this review several possibilities of an individualized hormonal therapy of the advanced breast cancer are discussed. Tumors selected for hormonal therapy on the basis of a positive estrogen receptor respond to endocrine therapy at nearly twice the rate of those chosen by clinical criteria alone. The overall response can be predicted with an accuracy of about 75 per cent. Furthermore clinical tests like short time treatment with L-dopa or testosterone are liable for many subjective mistakes. If the multivalent analyse of various prognostic criteria will be better for predicting the mistakes. If the multivalent analyse of various prognostic criteria will be better for predicting the hormone sensitivity is up to now unknown. The paper gives several guides for the ablative and additive hormonal therapies.
本综述讨论了晚期乳腺癌个体化激素治疗的几种可能性。基于雌激素受体阳性选择进行激素治疗的肿瘤，其对内分泌治疗的反应率几乎是仅根据临床标准选择的肿瘤的两倍。总体反应的预测准确率约为75%。此外，像左旋多巴或睾酮的短期治疗等临床试验容易出现许多主观错误。目前尚不清楚对各种预后标准进行多价分析是否更有利于预测错误。对各种预后标准进行多价分析是否更有利于预测激素敏感性目前尚不清楚。本文给出了一些关于消融性和补充性激素治疗的指南。
