Klinkmann H, Ratner M, Serov V V, Nizze H, Rosenfeld B I, Sinn W, Schmicker R
Proc Eur Dial Transplant Assoc. 1983;19:679-85.
In 135 patients with different glomerular diseases but normal glomerular filtration rates (CCr and In = 103 +/- 2ml/min) correlations between morphological tubular lesions (tic) and changes in tubular function were investigated. Between the extent of tubular lesions and the impairment of specific tubular functions (formula; see text) exists a highly significant correlation. The combined diminution in Uosmmax and UNH4 + V reflects in 72 per cent the appearance of a severe tubular lesion and should be used for its clinical recognition.
