Lepore F, Phaneuf J, Samson A, Guillemot J P
Behav Brain Res. 1982 Aug;5(4):359-74. doi: 10.1016/0166-4328(82)90040-7.
The present experiment was carried out to determine whether the memory trace of a pattern discrimination learned with one hemisphere is also transmitted to the second hemisphere via the corpus callosum or whether the trace is limited to the trained hemisphere and becomes accessible to the second during recall via this route. Split-chiasma cats learned two pattern discriminations with one eye (and hemisphere), then were subjected to a mid-sagittal transection of their corpus callosum, followed by learning with the other untrained eye (and hemisphere). Ten cats were separated into two groups: one group learned the discrimination to criterion (the non-overtrained group) while the other received 1600 overtraining trials over and beyond those needed to reach criterion (the overtrained group). Results indicated that there was little bilateral storage in the non-overtrained group (as determined by the number of trials needed to attain criterion with the second eye). Most subjects from the overtrained group showed chance performance during the first transfer session but learned the pattern discrimination much more rapidly with the second eye than with the first. These results are taken as indicating that memory transcription is possible through the callosum but that this route is slower and its readout is possibly contaminated by secondary non-specific factors which affect the initial utilization of the trace.
本实验旨在确定通过一个半球学习的模式辨别记忆痕迹是否也通过胼胝体传递到第二个半球，或者该痕迹是否仅限于受过训练的半球，并在回忆时通过这条途径被第二个半球获取。交叉视神经切断的猫用一只眼睛（和一个半球）学习两种模式辨别，然后对它们的胼胝体进行矢状面中部横切，接着用另一只未受过训练的眼睛（和另一个半球）学习。10只猫被分成两组：一组学习辨别直至达到标准（未过度训练组），而另一组在达到标准所需的试验次数之外还接受了1600次过度训练试验（过度训练组）。结果表明，未过度训练组几乎没有双侧存储（由用第二只眼睛达到标准所需的试验次数确定）。过度训练组的大多数受试者在第一次转换训练期间表现出随机水平，但用第二只眼睛学习模式辨别比用第一只眼睛快得多。这些结果被认为表明记忆转录可以通过胼胝体进行，但这条途径较慢，并且其读出可能受到影响痕迹初始利用的次要非特异性因素的干扰。
