Broccali G, Peviani N, Nusdeo O, Dorigotti L
Boll Ist Sieroter Milan. 1982 Mar;61(1):58-63.
The fixed combination (10 : 3) of amoxycillin and S-carboxymethylcysteine, which is indicated in the therapy of the respiratory tract infections, was given to rats by oral route to determine the blood levels and the concentrations in the pulmonary parenchyma and pleural exudate. In comparison with the antibiotic alone the combination determined higher levels of amoxycillin in the blood (0.5, 1.2 hours after administration) in the homogenized lung tissue (2 hours after administration) and in pleural inflammatory exudate (0.5, 1, 2 hours after administration) caused by intrapleural injection of carrageenan. The enhanced distribution of the antibiotic in the target tissues further supports the clinical usefulness of this combination.
阿莫西林与S-羧甲基半胱氨酸的固定组合（10:3）适用于呼吸道感染的治疗，通过口服途径给予大鼠，以测定血液水平、肺实质和胸腔渗出液中的浓度。与单独使用抗生素相比，该组合在给药后0.5、1.2小时的血液中、给药后2小时的匀浆肺组织中以及因胸腔内注射角叉菜胶引起的胸腔炎性渗出液中（给药后0.5、1、2小时），阿莫西林的水平更高。抗生素在靶组织中分布的增强进一步支持了该组合的临床实用性。
