Miglioli P A, Xerri L, Palatini P
Department of Pharmacology, University of Padova, Italy.
Pharmacology. 1991;43(5):242-6. doi: 10.1159/000138851.
The influence of the mode of intravenous (i.v.) administration (bolus injection or continuous infusion) on the tissue penetration of ceftazidime was studied in the rat. The antibiotic concentration was monitored in serum, pleural exudate, vitreous humor, kidney, liver, lung, testicles and epididymal fat tissue. Administration as a bolus resulted in a significantly higher AUC in pleural exudate and in higher peak levels in serum, liver and lung than continuous infusion, which produced a higher peak concentration in kidney than a bolus. No differences in AUC and peak concentrations between the two methods of administration were observed in the other tissues or fluids. With either method of administration the highest antibiotic accumulation was observed in kidney.
在大鼠中研究了静脉注射（i.v.）给药方式（推注或持续输注）对头孢他啶组织渗透的影响。监测血清、胸腔渗出液、玻璃体液、肾脏、肝脏、肺、睾丸和附睾脂肪组织中的抗生素浓度。推注给药导致胸腔渗出液中的AUC显著更高，血清、肝脏和肺中的峰值水平高于持续输注，而持续输注在肾脏中产生的峰值浓度高于推注。在其他组织或液体中，两种给药方法之间的AUC和峰值浓度没有差异。无论采用哪种给药方法，在肾脏中观察到的抗生素蓄积量最高。
