Valli P, Rossi M L, Gilberti G
Boll Soc Ital Biol Sper. 1982 Jul 15;58(13):834-40.
The action of the veratrum alkaloid veratridine has been tested on the sensory apparatus of the frog semicircular canals. Intracellular and extracellular recordings of the electrical responses evoked by sinusoidal mechanical stimulations of the ampullar organ could not reveal an action of the drug on the hair cells whereas the onset of the impulse discharge at the encoder of the afferent nerve fibres is largely facilitated by veratridine. The mechanism of the drug action is discussed.
藜芦生物碱藜芦定对青蛙半规管感觉器官的作用已经过测试。对壶腹器官进行正弦机械刺激所诱发的电反应进行细胞内和细胞外记录,未发现该药物对毛细胞有作用,而藜芦定在很大程度上促进了传入神经纤维编码处冲动发放的起始。文中讨论了该药物作用的机制。