藜芦定对灌注猫肾上腺释放儿茶酚胺的作用
Release of catecholamines from perfused cat adrenal gland by veratridine.
作者信息
Kirpekar S M, Prat J C
出版信息
Proc Natl Acad Sci U S A. 1979 Apr;76(4):2081-3. doi: 10.1073/pnas.76.4.2081.
Abstract
Experiments were undertaken to verify the existence of fast sodium channels in the adrenal chromaffin cell membrane and to assess their contribution to the physiological release of catecholamines. We have used veratridine to activate sodium channels. Veratridine causes secretion of catecholamines from perfused cat adrenal gland. Secretory response to veratridine is calcium dependent and abolished by tetrodotoxin. Secretion of catecholamines by acetylcholine is only partially blocked by tetrodotoxin. It is concluded that the adrenal chromaffin cell membrane contains fast sodium channels directly comparable to those of impulse-propagating neurons, but they do not appear to be essential in the secretory response to acetylcholine or splanchnic nerve stimulation.
摘要
进行了实验以验证肾上腺嗜铬细胞膜中快速钠通道的存在，并评估它们对儿茶酚胺生理释放的贡献。我们使用藜芦碱来激活钠通道。藜芦碱可引起灌注猫肾上腺分泌儿茶酚胺。对藜芦碱的分泌反应是钙依赖性的，并被河豚毒素所消除。乙酰胆碱引起的儿茶酚胺分泌仅被河豚毒素部分阻断。结论是，肾上腺嗜铬细胞膜含有与冲动传导神经元的快速钠通道直接相当的通道，但它们在对乙酰胆碱或内脏神经刺激的分泌反应中似乎并非必不可少。
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