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[急性摄入乙醇对I型糖尿病患者若干代谢参数(血糖、甘油三酯、非酯化脂肪酸、乳酸和尿酸)的影响]

[Effects of acute ingestion of ethanol on several metabolic parameters (blood sugar, triglycerides, non-esterified fatty acids, lactic acid and uric acid) in subjects with type I diabetes mellitus].

作者信息

Botta R M, Sinagra D, Migliore M G, Verga S

出版信息

Boll Soc Ital Biol Sper. 1982 Aug 15;58(15):958-63.

PMID:7126370
Abstract

7 diabetic type I patients and 17 normal subjects underwent to acute ethanol oral load (0,8 g/Kg), in order to investigate the modifications produced on glucose, triglycerides, FFA, lactate and uric acid plasma values. Our results show basal differences between diabetics and controls in all these parameters; furthermore, acute ethanol ingestion produces no significant variations of blood glucose in both groups, a significant decrease in FFA levels, an increase of triglyceridemic levels, more evident in diabetics and an increase of lactate, earlier in normals. On the other hand, there is no significant modification in uric acid plasma levels in controls, whereas in diabetics there is an increase, probably due to more elevated lactacidemic values in the late phase of the test.

摘要

7名I型糖尿病患者和17名正常受试者接受了急性口服乙醇负荷试验(0.8克/千克),以研究其对血糖、甘油三酯、游离脂肪酸(FFA)、乳酸和尿酸血浆值产生的变化。我们的结果显示,糖尿病患者和对照组在所有这些参数上存在基线差异;此外,急性摄入乙醇后,两组的血糖均无显著变化,FFA水平显著降低,甘油三酯水平升高,在糖尿病患者中更为明显,乳酸水平升高,在正常人中出现得更早。另一方面,对照组的尿酸血浆水平无显著变化,而糖尿病患者的尿酸水平升高,这可能是由于试验后期乳酸血症值升高所致。

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