McInnes G T, Shelton J R, Harrison I R, Perkins R M, Rigby G V
Br J Clin Pharmacol. 1982 Sep;14(3):449-52. doi: 10.1111/j.1365-2125.1982.tb02007.x.
Plasma potassium and aldosterone responses to 9 days treatment with hydrochlorothiazide (100 mg/day) alone or in combination with spironolactone (100 mg/day), prescribed once daily or in doses 12 h apart, were examined in a double-blind, crossover study in twelve healthy subjects. Plasma potassium concentrations were lower when the drugs were administered 12 h apart (P less than 0.01). Spironolactone attenuated significantly hydrochlorothiazide induced hypokalaemia--mean rise in plasma potassium, 0.36 mmol/l (P less than 0.001). The increase in plasma aldosterone was greater following combination therapies (P less than 0.001), but there were no significant differences between once daily and twice daily regimens. We conclude that plasma potassium concentration is better maintained when diuretics are given once daily and that this is not related closely to differences in plasma aldosterone responses.
在一项针对12名健康受试者的双盲交叉研究中，检测了单独使用氢氯噻嗪（100毫克/天）或与螺内酯（100毫克/天）联合使用，每日给药一次或间隔12小时给药9天对血浆钾和醛固酮的影响。当药物间隔12小时给药时，血浆钾浓度较低（P小于0.01）。螺内酯可显著减轻氢氯噻嗪诱导的低钾血症——血浆钾平均升高0.36毫摩尔/升（P小于0.001）。联合治疗后血浆醛固酮的升高幅度更大（P小于0.001），但每日一次和每日两次给药方案之间没有显著差异。我们得出结论，利尿剂每日给药一次时血浆钾浓度能得到更好的维持，且这与血浆醛固酮反应的差异没有密切关系。
