Sagen N, Koller O, Haram K
Br J Obstet Gynaecol. 1982 Oct;89(10):802-5. doi: 10.1111/j.1471-0528.1982.tb05029.x.
The last maternal haemoglobin (Hb) concentration before delivery was related to the perinatal outcome in 87 non-anaemic women suffering from severe pre-eclampsia. Abnormally high Hb concentrations were found in most women with evidence of placental dysfunction. An inverse correlation was found between the centile weight of the newborn and the maternal Hb. Significantly higher Hb levels were found in pregnancies complicated by fetal growth retardation and perinatal distress compared with those in pregnancies with good outcomes. Particularly high levels were found in pregnancies that ended in perinatal deaths. The hypothesis is put forward that raised haemoconcentration during severe pre-eclampsia causes increased blood viscosity which predisposes to placental pathology and initiates a vicious circle.
87名患有重度子痫前期的非贫血女性分娩前的最后一次母体血红蛋白（Hb）浓度与围产期结局相关。在大多数有胎盘功能障碍证据的女性中发现Hb浓度异常升高。新生儿体重百分位数与母体Hb之间呈负相关。与结局良好的妊娠相比，患有胎儿生长受限和围产期窘迫的妊娠中Hb水平显著更高。在围产期死亡的妊娠中发现Hb水平特别高。有人提出这样的假说：重度子痫前期期间血液浓缩加剧导致血液粘度增加，这易引发胎盘病变并形成恶性循环。
