Ohta Y
Biol Reprod. 1982 Sep;27(2):308-11. doi: 10.1095/biolreprod27.2.308.
Adult female rats which had been ovariectomized on Day 1, 5, 10 or 20 of age invariably formed deciduomata in response to uterine trauma or an intraluminal oil-instillation given after injections of estradiol-17 beta for 3 days from Day 60 onward followed by daily injections of progesterone starting 2 days later. If the magnitude of the deciduomal response was estimated by the decidual cell reaction index, the responses were larger in these rats than in the animals ovariectomized as adults. Two groups of rats ovariectomized on Days 1 and 10 were transplanted subcutaneously with one ovary on Day 10. When subjected to deciduogenic stimuli, after removal of the grafts on the first day of estrus occurring after Day 60 followed by hormonal sensitization of the endometrium, the 2 groups of rats elicited deciduomal responses approximately the same in magnitude. These findings indicate that the neonatal ovary has little effect on the development and differentiation of the rat uterus.
在出生第1、5、10或20天接受卵巢切除的成年雌性大鼠，从第60天起连续3天注射17β-雌二醇，随后从2天后开始每日注射孕酮，在此之后，若对其子宫造成创伤或向子宫腔内注入油剂，它们总会形成蜕膜。如果通过蜕膜细胞反应指数来评估蜕膜反应的程度，这些大鼠的反应比成年后才接受卵巢切除的动物更大。两组分别在第1天和第10天接受卵巢切除的大鼠，在第10天皮下移植了一个卵巢。在第60天后出现的第一个发情日去除移植的卵巢，随后对子宫内膜进行激素致敏，再给予蜕膜形成刺激时，这两组大鼠引发的蜕膜反应程度大致相同。这些发现表明，新生卵巢对大鼠子宫的发育和分化影响很小。
