[Lysosomotropic properties of polyvinylpyrrolidone (an experimental study].

Three-fold administration of polyvinylpyrrolidone (PVP), molecular weight 24 000, in a dose of 3.3 ml of 0.6% solution per 100 g/bw to rats was accompanied by disorders of lysosomal integrity and increased vulnerability to damage of the particles in the hypotonic medium (as judged from acid ribonuclease and cathepside D release). Five days after a single administration 125I-PVP was retained primarily by liver cells (7.3% of the dose administered) and to a lesser degree by renal cells (0.43%) and spleen cells (0.93%). Ninety per cent of the labeled PVP was bound to granular fractions of the rat liver (pinosomes, heterolysosomes). In the course of particles destruction by 0.1% Triton X-100 90% of 125I-PVP was released into the supernatant, which confirms the lysosomal localization of the compound.