Denechaud M, Commenges D
Bull Cancer. 1982;69(2):131-7.
The influence of the tumoral histological characters upon growth kinetics and cellular proliferation parameters was studied for autochtonous chemo-induced tumors in mice. In our experimental conditions, the initial minimum volume from which epithelial tumors on one hand and connective tumors on the other hand are observed and then follow a Gompertzian law, was defined. The change of the histological characters of malignancy was observed during the tumoral growth. Intermitotic delays, durations of the cell cycle phases, growth fraction and degree of cell loss were calculated for epithelial and connective tumors.
研究了肿瘤组织学特征对小鼠自发性化学诱导肿瘤生长动力学和细胞增殖参数的影响。在我们的实验条件下，确定了一方面观察到上皮性肿瘤、另一方面观察到结缔组织肿瘤并随后遵循Gompertzian定律的初始最小体积。在肿瘤生长过程中观察到恶性组织学特征的变化。计算了上皮性肿瘤和结缔组织肿瘤的分裂间期延迟、细胞周期各阶段的持续时间、生长分数和细胞丢失程度。
