[Influence of histological type on the kinetics of tumor growth and cellular proliferation in autochtonous tumors of mice].

The influence of the tumoral histological characters upon growth kinetics and cellular proliferation parameters was studied for autochtonous chemo-induced tumors in mice. In our experimental conditions, the initial minimum volume from which epithelial tumors on one hand and connective tumors on the other hand are observed and then follow a Gompertzian law, was defined. The change of the histological characters of malignancy was observed during the tumoral growth. Intermitotic delays, durations of the cell cycle phases, growth fraction and degree of cell loss were calculated for epithelial and connective tumors.