Hill S A, Denekamp J
Br J Radiol. 1982 Sep;55(657):651-6. doi: 10.1259/0007-1285-55-657-651.
It is proposed that histological assessment of tumours may be a useful biological thermal dosimeter. Assessment of nodules may give information about thermal gradients, and biopsies of treated tumours may serve as a prognostic indicator in clinical hyperthermia. Cell death after hyperthermia occurs rapidly and surviving cells are readily recognizable as small foci within 24 h. This contrasts with the delayed cell death and the more random distribution of survivors amongst killed cells after ionizing radiation. By 24 h, sections of tumours can demonstrate islands of apparently viable cells in a sea of necrosis after 44.8 degrees C/1 h. This technique has been used to identify regions of poor heating in mouse tumours treated by water immersion. Cells surrounding blood vessels and cells adjacent to underlying normal tissue were seen to be protected from thermal damage.
有人提出，肿瘤的组织学评估可能是一种有用的生物热剂量计。对结节的评估可以提供有关热梯度的信息，而对治疗后肿瘤的活检可以作为临床热疗中的预后指标。热疗后细胞死亡迅速发生，存活细胞在24小时内很容易被识别为小病灶。这与电离辐射后细胞死亡延迟以及存活细胞在死亡细胞中分布更随机的情况形成对比。到24小时时，肿瘤切片在44.8摄氏度/1小时后可显示出坏死区域中明显存活的细胞岛。该技术已被用于识别通过水浸治疗的小鼠肿瘤中加热不良的区域。可见血管周围的细胞和与下方正常组织相邻的细胞受到热损伤的保护。
