去甲脑啡肽-γ-内啡肽和去酪氨酸1-α-内啡肽对大鼠脑内局部5-羟色胺代谢的影响。

The effects of des-enkephalin-gamma-endorphin and des-Tyr1-a-endorphin on regional serotonin metabolism in rat brain.

作者信息

Versteeg D H, De Kloet E R, Szabó G, Kovács G L

出版信息

Brain Res. 1982 Aug 12;245(2):384-8. doi: 10.1016/0006-8993(82)90823-x.

Abstract

Des-enkephalin-gamma-endorphin (beta-endorphin6-17; DE gamma E) causes a significant reduction of the serotonin concentration of the raphe area of the mesencephalon and of the dorsal hippocampus of the rat. DE gamma E does not, however, alter the pargyline-induced accumulation of serotonin in either of these two brain regions or in the mediobasal hypothalamus. Des-Tyr1-a-endorphin (beta-endorphin2-16; DTaE), on the other hand, inhibits the accumulation of serotonin following MAO-inhibition by pargyline in all 3 brain regions, while, in addition to causing a transient reduction in the serotonin concentration of the raphe area, it decreases the serotonin concentration of the mediobasal hypothalamus. These results indicate that DE gamma E and DTaE, which have been shown to exert opposite effects on behavior in various behavioral tests, both affect regional serotonin metabolism in rat brain and that they do so differently.

摘要

去甲脑啡肽-γ-内啡肽（β-内啡肽6-17；DEγE）可使大鼠中脑缝际区和背侧海马体的5-羟色胺浓度显著降低。然而，DEγE并不会改变这两个脑区或中基底下丘脑内由优降宁诱导的5-羟色胺蓄积。另一方面，去酪氨酸-α-内啡肽（β-内啡肽2-16；DTaE）在所有这三个脑区中均抑制由优降宁抑制单胺氧化酶后所引起的5-羟色胺蓄积，同时，除了引起缝际区5-羟色胺浓度短暂降低外，它还会降低中基底下丘脑的5-羟色胺浓度。这些结果表明，在各种行为测试中已显示出对行为产生相反作用的DEγE和DTaE，均会影响大鼠脑内的局部5-羟色胺代谢，而且它们的影响方式有所不同。