Brelińska R, Pilgrim C
Cell Tissue Res. 1982;226(1):155-65. doi: 10.1007/BF00217090.
These studies were designed to gain more detailed information on the sites of lymphocyte migration into the marginal zone, on lymphocyte segregation within this area and on subsequent migration of the cells in individual compartments of the rat spleen. A lymphocyte population enriched in T-lymphocytes was obtained from rat lymph nodes and was labeled with 5-(3H)uridine in vitro. Observations on localization of labeled lymphocytes at short time intervals following their intravenous transfusion into syngeneic recipients, indicate that the sites of emigration from the blood are the internal and external layers of the marginal zone. From here, the cells migrate towards the periarteriolar lymphoid sheath and the red pulp.
这些研究旨在获取关于淋巴细胞迁移至边缘区的位点、该区域内淋巴细胞的分隔以及大鼠脾脏各个区域中细胞后续迁移的更详细信息。从大鼠淋巴结获得富含T淋巴细胞的淋巴细胞群体，并在体外用5-(3H)尿苷进行标记。在将标记的淋巴细胞静脉输注给同基因受体后短时间间隔内对其定位的观察表明，血液中淋巴细胞逸出的位点是边缘区的内层和外层。从这里，细胞向动脉周围淋巴鞘和红髓迁移。
