Mellström B, Alván G, Bertilsson L, Potter W Z, Säwe J, Sjöqvist F
Clin Pharmacol Ther. 1982 Nov;32(5):664-7. doi: 10.1038/clpt.1982.219.
Oral (50 mg) and intramuscular (25 mg) amitriptyline (AT) was given to six normal subjects and the area under the plasma concentration-time curve (AUC) for nortriptyline (NT) formed was calculated. There was no difference between the AUCs (corrected for dose) after the two routes of administration. The ratio between the AUCs (corrected for dose) after the two routes of administration. The ratio between AUCoral and AUCim averaged 0.95 (range 0.69 to 1.13). After intramuscular AT maximum NT plasma concentration was reached after 24 to 48 hr, whereas it was 8 to 24 after oral dosing.
给6名正常受试者口服（50毫克）和肌肉注射（25毫克）阿米替林（AT），并计算形成的去甲替林（NT）的血浆浓度-时间曲线下面积（AUC）。两种给药途径后的AUC（校正剂量后）无差异。两种给药途径后AUC（校正剂量后）的比值。口服AUC与肌肉注射AUC的比值平均为0.95（范围为0.69至1.13）。肌肉注射AT后，24至48小时达到NT血浆最大浓度，而口服给药后为8至24小时。
