用弗勒里HEP 675株对野生欧洲哺乳动物进行的安全性试验。

Safety tests with Flury HEP strain 675 in wild-living European mammals.

作者信息

Wachendörfer G, Kiefert C, Frost J W

出版信息

Comp Immunol Microbiol Infect Dis. 1982;5(1-3):177-80. doi: 10.1016/0147-9571(82)90033-9.

Abstract

For the evaluation of residual pathogenicity of Flury HEP strain 675, the vaccinal virus was orally administered to 207 animals belonging to 15 wild-living and 1 domestic species. Rabies virus antigen could be demonstrated by FA method in 20 animals. Reisolation of the virus was possible from 23 animals within the first two weeks after application, the titres being very low. During the observation period of 100 days no symptoms of rabies could be observed in the animals tested.

摘要

为评估Flury HEP 675株疫苗病毒的残余致病性，将该疫苗病毒经口接种于15种野生动物和1种家养动物的207只动物。通过荧光抗体法（FA法）在20只动物体内检测到狂犬病病毒抗原。接种后的前两周内，从23只动物体内成功分离出病毒，但其滴度很低。在100天的观察期内，未在受试动物中观察到狂犬病症状。