用弗勒里HEP 675株对狐狸进行口服狂犬病疫苗接种的有效性。
Effectivity of oral vaccination of foxes against rabies with Flury HEP strain 675.
作者信息
Frost J W, Friedrich H, Wachendörfer G
出版信息
Comp Immunol Microbiol Infect Dis. 1982;5(1-3):181-4. doi: 10.1016/0147-9571(82)90034-0.
A group of 14 adult foxes was orally vaccinated with 2 ml Flury HEP strain 675, titre 10(8.2 TCID50. Each fox seroconverted neutralizing antibody titres ranging between 1:40 and 1:640. These foxes survived an intramuscular challenge with 8000 mouse LD50 pathogenic rabies virus, whereas six out of seven unprotected control foxes died within 28 days. This study was accompanied by virus isolation, fluorescence microscopic examination and neutralization tests.
给一组14只成年狐狸口服接种2毫升Flury HEP毒株675，滴度为10(8.2)TCID50。每只狐狸的血清转化中和抗体滴度在1:40至1:640之间。这些狐狸在接受8000个小鼠LD50致病性狂犬病病毒的肌肉注射攻击后存活下来，而7只未受保护的对照狐狸中有6只在28天内死亡。这项研究还进行了病毒分离、荧光显微镜检查和中和试验。
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