Lawson K F, Chiu H, Crosgrey S J, Matson M, Casey G A, Campbell J B
Ontario Ministry of Natural Resources, Wildlife and Natural Heritage Science Section, Maple.
Can J Vet Res. 1997 Jan;61(1):39-42.
Red foxes (Vulpes vulpes) vaccinated orally with the ERA strain of rabies vaccine in a bait were challenged after 83 mo. Ten of 11 foxes that had seroconverted following vaccination resisted challenge with a virulent rabies virus which produced clinical signs of rabies in 6 of 6 unvaccinated foxes. Five of 11 vaccinated animals retained titers of rabies virus neutralizing antibody throughout the period. Although 6 of 11 had no detectable antibody at the time of challenge, 5 of these 6 resisted challenge and had an anamnestic response, as indicated by elevated titers of antibody when measured at day 77 postchallenge. These results show that foxes can be immunized successfully with a single oral dose of ERA vaccine, probably with protection against a lethal rabies challenge, for at least 7 y.
给红狐（赤狐）口服含狂犬病疫苗ERA株的诱饵，83个月后进行攻毒试验。11只接种疫苗后血清阳转的狐狸中，有10只抵抗了强毒狂犬病病毒的攻毒，而6只未接种疫苗的狐狸全部出现了狂犬病临床症状。11只接种疫苗的动物中有5只在整个观察期内都保持着狂犬病病毒中和抗体滴度。虽然11只中有6只在攻毒时未检测到抗体，但这6只中的5只抵抗了攻毒并出现了回忆反应，攻毒后77天检测时抗体滴度升高。这些结果表明，红狐单次口服ERA疫苗即可成功免疫，可能至少7年都能抵御致命的狂犬病攻毒。
