Artois M, Cliquet F, Barrat J, Schumacher C L
CNEVA Nancy, Laboratoire d'études sur la rage et la pathologie des animaux sauvages, Malzéville, France.
Vet Rec. 1997 Jan 18;140(3):57-9. doi: 10.1136/vr.140.3.57.
Three groups of 10 foxes were vaccinated by the direct oral instillation of 2 ml of SAG1 rabies virus vaccine containing 10(6) MICLD50 (10(7) TCID50/ml) infectious viral particles/ml. SAG1 is a natural variant of the attenuated rabies vaccine strain SAD Bern and was selected in the presence of monoclonal antibodies. The strain is devoid of residual pathogenicity for the fox and the highly susceptible adult laboratory mouse by the oral, intramuscular and intracerebral routes. The foxes were challenged six, 12 and 18 months later with a virulent vulpine street rabies virus (GS 7-1-1). They all survived, whereas seven of eight unvaccinated control foxes died.
将三组各10只狐狸通过直接口服2毫升含有10⁶ 半数感染量（MICLD50）（10⁷ 组织培养感染剂量50/ml）感染性病毒颗粒/毫升的SAG1狂犬病病毒疫苗进行接种。SAG1是减毒狂犬病疫苗株SAD Bern的自然变体，是在单克隆抗体存在的情况下筛选出来的。该毒株通过口服、肌肉注射和脑内注射途径对狐狸和高度易感的成年实验小鼠均无残余致病性。6个月、12个月和18个月后，用强毒性狐狸街狂犬病病毒（GS 7-1-1）对这些狐狸进行攻击。它们全部存活，而8只未接种疫苗的对照狐狸中有7只死亡。
