Rudy M A, Zigman S, Girsch S J, Schenk E
Curr Eye Res. 1982;2(1):39-45. doi: 10.3109/02713688208998378.
Monocularly aphakic guinea pigs (Cavia porcellis), prepared by removing the lens by phacoemulsification, were maintained under near-UV lighting conditions for several months. Exposure to near-UV energy was at much lower irradiance levels than that of sunlight, and was at lower than the threshold level for near-UV damage to the aphakic monkey retina as reported by Ham, et al (1). In some aphakic eyes, regenerated lens-like structures formed which scattered light appreciably. After increasing light exposure periods, the eyes of control and irradiated animals were studied histologically. Other animals were periodically examined by electroretinographic (ERG) techniques. While there was no observable histopathological damage, aphakic-UV irradiated eyes with little or no lens regrowth exhibited depressed b-waves, late time constants and altered wave forms when compared with control eyes. The results demonstrate that ambient near-UV light exposure can adversely influence retinal electrical activity in aphakic eyes at irradiance levels below threshold for morphological damage. The protective function of the lens is also supported by these findings.
通过超声乳化摘除晶状体制备的单眼无晶状体豚鼠（豚鼠），在近紫外光照明条件下饲养数月。暴露于近紫外能量的辐照度水平远低于阳光，且低于Ham等人（1）报道的无晶状体猴视网膜近紫外损伤阈值水平。在一些无晶状体眼中，形成了再生的晶状体样结构，明显散射光线。在增加光照暴露时间后，对对照动物和辐照动物的眼睛进行了组织学研究。其他动物定期用电视网膜图（ERG）技术进行检查。虽然没有观察到组织病理学损伤，但与对照眼相比，晶状体再生很少或没有的无晶状体-紫外线辐照眼表现出b波降低、延迟时间常数和波形改变。结果表明，在低于形态学损伤阈值的辐照度水平下，环境近紫外光暴露会对无晶状体眼的视网膜电活动产生不利影响。这些发现也支持了晶状体的保护功能。
