Morton N E, Hassold T J, Funkhouser J, McKenna P W, Lew R
Cytogenet Cell Genet. 1982;33(3):232-9. doi: 10.1159/000131759.
During the five years of a cytogenetic study on spontaneous abortions in Hawaii there have been significant increases in the frequencies of triploidy of maternal origin and trisomy 16, a significant decrease in sex chromosome monosomy, and variation without trend in the frequency of tetraploidy. Attempts to explain these results in terms of technical factors or changes in maternal and gestational age have been unsuccessful, as have preliminary attempts to identify viral, pharmacological, or other causes. Apparently the etiology of chromosomal abnormality is variable over a few years even in a stable population. Research to identify these causes is continuing on the supposition that variable risks can be reduced.
在对夏威夷自然流产进行细胞遗传学研究的五年间，母源性三倍体和16三体的频率显著增加，性染色体单体频率显著下降，四倍体频率则无趋势变化。试图从技术因素或母亲年龄及孕期变化方面解释这些结果均未成功，初步尝试确定病毒、药物或其他病因也未成功。显然，即使在稳定人群中，染色体异常的病因在几年内也是可变的。基于可变风险可降低这一假设，确定这些病因的研究仍在继续。
