Hassold T J, Matsuyama A, Newlands I M, Matsuura J S, Jacobs P A, Manuel B, Tsuei J
Ann Hum Genet. 1978 May;41(4):443-54. doi: 10.1111/j.1469-1809.1978.tb00914.x.
Cytogenetic results on 234 spontaneous abortions showed 109 (46.6%) to have a chromosome abnormality. The results were analysed separately for the four major ethnic groups of which the population was composed and no differences in the proportion or types of chromosome abnormalities seen. The results of this survey were found to be very similar to other major published surveys and it therefore appears, on present evidence, that neither geographic location nor racial group affects the frequency of chromosome abnormalities seen among human spontaneous abortions. The sex ratio among the chromosomally normal and abnormal abortuses and the effect of parental and gestational age were discussed.
对234例自然流产进行的细胞遗传学检测结果显示,109例(46.6%)存在染色体异常。针对构成该人群的四个主要种族群体分别分析了结果,未发现染色体异常的比例或类型存在差异。本次调查结果与其他已发表的主要调查结果非常相似,因此,根据目前的证据来看,地理位置和种族群体似乎均不影响人类自然流产中染色体异常的发生率。文中还讨论了染色体正常和异常流产胎儿的性别比例以及父母年龄和妊娠年龄的影响。