甲基丙烯酸烯丙酯对豚鼠的皮肤致敏潜力。
Skin sensitization potential of allyl methacrylate in guinea pigs.
作者信息
Siddiqui W H, DeVries C R, Hobbs E J
出版信息
Drug Chem Toxicol. 1982;5(2):183-7. doi: 10.3109/01480548209017778.
The skin sensitization potential of allyl methacrylate (AMA) was studied in Hartley albino guinea pigs. Two groups of guinea pigs (10 per compound) were subjected to repeated insult patch tests either with AMA or with dinitrochlorobenzene (DNCB). All guinea pigs treated with DNCB (positive control) were sensitized. None of the guinea pigs treated with AMA exhibited any evidence of sensitization and no reactions attributable to AMA were elicited as a result of exposure during the insult phase of the patch test. Based on these results, it is concluded that allyl methacrylate is not likely to be a sensitizer and exposure to this material in industrial handling situations will not present an appreciable risk of human skin sensitization,
在哈特利白化豚鼠中研究了甲基丙烯酸烯丙酯（AMA）的皮肤致敏潜力。两组豚鼠（每种化合物10只）分别接受了AMA或二硝基氯苯（DNCB）的重复刺激斑贴试验。所有接受DNCB治疗的豚鼠（阳性对照）均被致敏。接受AMA治疗的豚鼠均未表现出任何致敏迹象，并且在斑贴试验的刺激阶段暴露后，未引发任何归因于AMA的反应。基于这些结果，得出结论：甲基丙烯酸烯丙酯不太可能是一种致敏剂，在工业操作环境中接触这种物质不会对人体皮肤致敏构成明显风险。
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