Armour C L, Nicholls I J, Schellenberg R R
Eur J Pharmacol. 1982 Aug 27;82(3-4):229-32. doi: 10.1016/0014-2999(82)90519-2.
Contraction of guinea pig tracheal smooth muscle was induced by leukotriene C4 or leukotriene D4. The inhibition of the smooth muscle contraction by salbutamol and theophylline was compared with the inhibition by FPL 55712. Salbutamol (5 X 10(-8) - 5 X 10(-7) M) significantly inhibited the leukotriene-induced contraction. The degree of inhibition was greater than that observed with FPL55712 (10(-6) - 10(-4) M). Theophylline (10(-6) - 10(-4) M) did not affect the leukotriene-induced contraction, but enhanced the effect of salbutamol when these agents were combined.
白三烯C4或白三烯D4可诱导豚鼠气管平滑肌收缩。将沙丁胺醇和茶碱对平滑肌收缩的抑制作用与FPL 55712的抑制作用进行了比较。沙丁胺醇（5×10⁻⁸ - 5×10⁻⁷M）显著抑制白三烯诱导的收缩。抑制程度大于用FPL55712（10⁻⁶ - 10⁻⁴M）观察到的程度。茶碱（10⁻⁶ - 10⁻⁴M）不影响白三烯诱导的收缩，但当这些药物联合使用时会增强沙丁胺醇的作用。
