Solomon R E, Herling S, Woods J H
Eur J Pharmacol. 1982 Aug 27;82(3-4):233-7. doi: 10.1016/0014-2999(82)90520-9.
Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at considerably higher doses than did PCP. A third monohydroxylated PCP metabolite produced only sham-appropriate responding. The results suggest that these PCP metabolites contribute little to the behavioral actions of PCP in the monkey.
恒河猴经过训练，能够区分盐水和氯胺酮注射液。在刺激泛化测试中，苯环己哌啶（PCP）在每只猴子身上产生了与剂量相关的、类似氯胺酮的反应。两种单羟基化的PCP代谢物也产生了类似氯胺酮的辨别效应，尽管其剂量远高于PCP。第三种单羟基化的PCP代谢物仅产生了类似安慰剂的反应。结果表明，这些PCP代谢物对猴子体内PCP的行为作用贡献不大。
