Vecchini A, Binaglia L, Porcellati G
Farmaco Sci. 1982 Aug;37(8):537-42.
The uptake of labelled cytidine from primary cell cultures from rat embryo brain has been examined in the presence of uridine and glutamine. When uridine and glutamine are incubated with cytidine at a ten-fold higher concentration cytidine uptake is stimulated noticeably but its conversion into cytidine nucleotides is inhibited. When equimolar concentrations of uridine and glutamine are used, both cytidine uptake and metabolism are noticeably increased. The results point to interesting interactions among nucleosides for their transport into living cells and their further utilization.
在存在尿苷和谷氨酰胺的情况下，对来自大鼠胚胎脑的原代细胞培养物中标记胞苷的摄取进行了研究。当尿苷和谷氨酰胺与胞苷以高十倍的浓度一起孵育时，胞苷摄取明显受到刺激，但其转化为胞苷核苷酸的过程受到抑制。当使用等摩尔浓度的尿苷和谷氨酰胺时，胞苷摄取和代谢均显著增加。结果表明核苷在其转运到活细胞及其进一步利用过程中存在有趣的相互作用。
