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大鼠脑原代培养物中胞苷的摄取与利用

Cytidine uptake and utilization in primary culture from the rat brain.

作者信息

Vecchini A, Binaglia L, Palmerini C A, Floridi A, Porcellati G

出版信息

Ital J Biochem. 1981 Sep-Oct;30(5):367-74.

PMID:7327908
Abstract

The uptake of labelled cytidine from primary cell cultures from rat embryo brain has been studied. A preferential flow of the cytosine moiety towards CDP-choline is evident. Labelled uracyl derivatives represent only a small fraction of the radioactivity measured in the hydrosoluble fraction of the cell extract, at any incubation time. CDP-choline synthesized from labelled cytidine belongs to the metabolic pool implicated in phospholipid synthesis. The evidence for the uptake of the intact cytidine molecule is also given.

摘要

对来自大鼠胚胎脑的原代细胞培养物中标记胞苷的摄取进行了研究。胞嘧啶部分向CDP-胆碱的优先流动是明显的。在任何孵育时间,标记的尿嘧啶衍生物仅占细胞提取物水溶性部分中测得放射性的一小部分。由标记胞苷合成的CDP-胆碱属于参与磷脂合成的代谢池。同时也给出了完整胞苷分子摄取的证据。

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3
The transport of cytidine into rat brain in vivo, and its conversion into cytidine metabolites.
胞苷在大鼠体内向脑内的转运及其向胞苷代谢物的转化。
Neurochem Res. 1982 Oct;7(10):1199-207. doi: 10.1007/BF00965891.
4
The influence of cytidine on the endogenous pool of CDP-choline, CDP-ethanolamine, and CMP of the rat brain.胞苷对大鼠脑内CDP-胆碱、CDP-乙醇胺和CMP内源性库的影响。
Neurochem Res. 1984 Jan;9(1):73-9. doi: 10.1007/BF00967660.