A comparison of hepatic adenylosuccinate lyase from rats fed either a chow diet or a semisynthetic basal diet low in riboflavin.

1. AMPS Lyase which shows increased activity in both transplantable and primary hepatomas has been purified approximately 400-fold from both chow fed and basal fed rat liver. 2. The enzyme from basal fed rats shows subtle but significant differences from the enzyme from chow fed rats. Especially noted was the difference in effect of 100 mM Na+ on the enzyme from the two different sources after the whole liver had been frozen. 3. These differences may be related to the effects of starvation followed by refeeding or administration of either glucose or corn oil.