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Importance of the alkylaminoethoxy side-chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus.

作者信息

Jordan V C, Gosden B

出版信息

Mol Cell Endocrinol. 1982 Aug;27(3):291-306. doi: 10.1016/0303-7207(82)90095-8.

DOI:10.1016/0303-7207(82)90095-8
PMID:7128917
Abstract
摘要

相似文献

1
Importance of the alkylaminoethoxy side-chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus.
Mol Cell Endocrinol. 1982 Aug;27(3):291-306. doi: 10.1016/0303-7207(82)90095-8.
2
Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor.未成熟大鼠子宫中的抗雌激素差异作用：对雌激素受体具有高亲和力的羟基化抗雌激素的比较。
J Steroid Biochem. 1983 Sep;19(3):1249-58. doi: 10.1016/0022-4731(83)90147-4.
3
In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen.3-羟基他莫昔芬、他莫昔芬和4-羟基他莫昔芬的体内和体外抗雌激素作用。
Eur J Cancer Clin Oncol. 1985 Aug;21(8):985-90. doi: 10.1016/0277-5379(85)90119-1.
4
Opposing biological actions of antiestrogens in vitro and in vivo: induction of progesterone receptor in the rat and mouse uterus.抗雌激素在体外和体内的相反生物学作用：大鼠和小鼠子宫中孕酮受体的诱导
Endocrinology. 1985 Jun;116(6):2327-36. doi: 10.1210/endo-116-6-2327.
5
Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018.短效抗雌激素LY117018对雌激素和抗雌激素子宫促生长活性的抑制作用
Endocrinology. 1983 Aug;113(2):463-8. doi: 10.1210/endo-113-2-463.
6
Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens.一系列非甾体抗雌激素的抗雌激素和抗肿瘤活性
J Endocrinol. 1983 Dec;99(3):455-64. doi: 10.1677/joe.0.0990455.
7
Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity.他莫昔芬不可异构化衍生物的构效关系：羟基和侧链位置对生物活性的重要性。
Mol Pharmacol. 1991 Mar;39(3):421-8.
8
Effects of daily anti-estrogen treatment on uterine growth and progesterone receptor concentrations in adult rat uterus.每日抗雌激素治疗对成年大鼠子宫生长及孕酮受体浓度的影响。
Anticancer Res. 1984 May-Jun;4(3):157-62.
9
Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice.他莫昔芬、三苯氧胺及一种新型雌激素拮抗剂（LY117018）在大鼠和小鼠中的子宫生物测定
Life Sci. 1980 Apr 28;26(17):1453-8. doi: 10.1016/0024-3205(80)90049-1.
10
Evidence for biological action of the antiestrogens LY117018 and tamoxifen by different mechanisms.抗雌激素药物LY117018和他莫昔芬通过不同机制产生生物学作用的证据。
Endocrinology. 1981 Sep;109(3):987-9. doi: 10.1210/endo-109-3-987.

引用本文的文献

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The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.形成类雌激素的他莫昔芬代谢物及其对 ADME 基因的酶活性和基因表达的影响。
Arch Toxicol. 2018 Mar;92(3):1099-1112. doi: 10.1007/s00204-017-2147-y. Epub 2017 Dec 28.
2
The effects of endoxifen and other major metabolites of tamoxifen on the sulfation of estradiol catalyzed by human cytosolic sulfotransferases hSULT1E1 and hSULT1A1*1.他莫昔芬的内昔芬及其他主要代谢产物对人胞质硫酸转移酶hSULT1E1和hSULT1A1*1催化的雌二醇硫酸化作用的影响。
Drug Metab Dispos. 2015 Jun;43(6):843-50. doi: 10.1124/dmd.115.063206. Epub 2015 Mar 27.
3
Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1).
他莫昔芬的内昔芬及其他代谢产物可抑制人羟基类固醇磺基转移酶2A1（hSULT2A1）。
Drug Metab Dispos. 2014 Nov;42(11):1843-50. doi: 10.1124/dmd.114.059709. Epub 2014 Aug 25.
4
Synthesis and biological activity of 3-N-substituted estrogen derivatives as breast cancer agents.合成及 3-N-取代雌激素衍生物的生物活性作为乳腺癌治疗剂。
Mini Rev Med Chem. 2013 Jul;13(9):1381-8. doi: 10.2174/1389557511313090012.
5
New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.他莫昔芬代谢的新见解及其在乳腺癌治疗和预防中的作用。
Steroids. 2007 Nov;72(13):829-42. doi: 10.1016/j.steroids.2007.07.009. Epub 2007 Jul 27.
6
Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells.雷洛昔芬 - 雌激素受体α复合物在调节乳腺癌细胞中转化生长因子α表达方面的结构 - 功能关系
J Biol Chem. 2002 Mar 15;277(11):9189-98. doi: 10.1074/jbc.M108335200. Epub 2001 Dec 20.
7
The estrogen receptor: a logical target for the prevention of breast cancer with antiestrogens.雌激素受体：抗雌激素预防乳腺癌的合理靶点。
J Mammary Gland Biol Neoplasia. 1999 Oct;4(4):401-13. doi: 10.1023/a:1018722502034.
8
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.制定抗雌激素辅助治疗乳腺癌一般原则的实验室研究：问题与未来临床应用潜力
Breast Cancer Res Treat. 1983;3 Suppl:S73-86. doi: 10.1007/BF01855131.
9
Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance.他莫昔芬在动物和人体内的代谢产物：鉴定、药理学及意义
Breast Cancer Res Treat. 1982;2(2):123-38. doi: 10.1007/BF01806449.
10
Acetoxy substituted 1,1,2-triphenylbut-1-enes: estrogenic, antiestrogenic and mammary tumor inhibiting activity.乙酰氧基取代的1,1,2-三苯基丁-1-烯：雌激素活性、抗雌激素活性及抑制乳腺肿瘤活性
J Cancer Res Clin Oncol. 1986;112(2):119-24. doi: 10.1007/BF00404393.