D600 对离体兔主动脉的作用。

Actions of D 600 on isolated rabbit aorta.

Auguet M, DeFeudis F V

Gen Pharmacol. 1982;13(4):343-6. doi: 10.1016/0306-3623(82)90055-6.

Abstract

The actions of D 600 (10(-9)-10(-4) M) on various phases of NE- or Ca2+-induced contractions of rabbit isolated aorta were determined in Ca2+-free medium. 2. D 600 inhibited the slow phase of contraction with EC50 approximately equal to 3 X 30(-8) M, but affected the rapid phase of contraction only at 10(-4) M. 3. D 600 increased the relaxation that followed the rapid phase of NE-induced contraction in Ca2+-free medium with EC50 approximately equal to 1.5 X 10(-5) M. 4. The method described might be useful for further studies on Ca2+-antagonists.

摘要

在无钙培养基中测定了D 600（10⁻⁹ - 10⁻⁴M）对去甲肾上腺素（NE）或钙离子（Ca²⁺）诱导的兔离体主动脉收缩各阶段的作用。2. D 600抑制收缩的慢相，其半数有效浓度（EC50）约等于3×10⁻⁸M，但仅在10⁻⁴M时影响收缩的快相。3. D 600增强了无钙培养基中NE诱导的收缩快相后的舒张，其EC50约等于1.5×10⁻⁵M。4. 所描述的方法可能对进一步研究钙拮抗剂有用。