银杏叶提取物及多种物质对离体兔主动脉收缩的相性和紧张性成分的影响。

Effects of an extract of Ginkgo biloba and diverse substances on the phasic and tonic components of the contraction of an isolated rabbit aorta.

Auguet M, Clostre F

Gen Pharmacol. 1983;14(2):277-80. doi: 10.1016/0306-3623(83)90010-1.

Abstract

The effects of phentolamine, propranolol, D 600, theophylline, papaverine and an extract of Ginkgo biloba were studied with respect to the two phases of the contractile response induced by norepinephrine in an isolated rabbit aorta. 2. Phentolamine (3 x 10(-6) M) inhibits the rapid phase of the contraction of the rabbit aorta brought on by norepinephrine (NE) 10(-5) M more strongly than the tonic phase. Propranolol (10(-6) M) potentiates this rapid phase. 3. D 600 inhibits the slow phase with an EC50 = to 3.8 x 10(-8) M. 4. Papaverine and theophylline increase the relaxation that follows the rapid phase of contraction. The slow phase is inhibited only by papaverine. 5. The extract of Ginkgo biloba (Gb) at a concentration of 3 mg/ml has the same type of effect as papaverine 3 X 10(-5) M.

摘要

研究了酚妥拉明、普萘洛尔、D600、茶碱、罂粟碱和银杏叶提取物对去甲肾上腺素诱导的离体兔主动脉收缩反应两个阶段的影响。2. 酚妥拉明（3×10⁻⁶M）比抑制去甲肾上腺素（NE）10⁻⁵M引起的兔主动脉收缩的强直相更强烈地抑制其快速相。普萘洛尔（10⁻⁶M）增强此快速相。3. D600以EC50 = 3.8×10⁻⁸M抑制慢相。4. 罂粟碱和茶碱增加收缩快速相后的舒张。仅罂粟碱抑制慢相。5. 浓度为3mg/ml的银杏叶提取物（Gb）具有与3×10⁻⁵M罂粟碱相同类型的作用。