Droste U, Siemens P
Fortschr Med. 1982 Aug 5;100(29):1374-6.
The efficacy and tolerability of slow-release diclofenac sodium were investigated in 40 patients with ankylosing spondylitis. The patients received one coated tablet of 100 mg daily in the morning for 21 days in addition to standard physiotherapy. The efficacy of the trial treatment was evaluated by measuring the chin-to-manubrium sterni and fingertips-to-floor distances, Schober's sign, and chest expansion. Every morning and evening the severity of pain and the degree of spinal stiffness were recorded by the patients on visual analogue scales. A significant improvement of the symptoms was found in 35 of the patients as compared to the initial findings. The slow-release formulation of diclofenac Na was very well tolerated. The necessity of balneophysical therapy in ankylosing spondylitis is emphasized, which in most cases will only be possible in combination with adequate drug therapy.
对40例强直性脊柱炎患者研究了缓释双氯芬酸钠的疗效和耐受性。除标准物理治疗外，患者每天早晨服用1片100mg包衣片，共21天。通过测量颏至胸骨柄及指尖至地面的距离、Schober征和胸廓活动度来评估试验治疗的疗效。患者每天早晚用视觉模拟评分法记录疼痛严重程度和脊柱僵硬程度。与初始结果相比，35例患者的症状有显著改善。双氯芬酸钠缓释制剂耐受性良好。强调了强直性脊柱炎中浴疗物理治疗的必要性，在大多数情况下，这只有与适当的药物治疗联合才有可能。
