小网格可溶性免疫复合物的消失动力学及肾小球沉积
The disappearance kinetics and glomerular deposition of small-latticed soluble immune complexes.
作者信息
Haakenstad A O, Striker G E, Mannik M
出版信息
Immunology. 1982 Nov;47(3):407-14.
The disappearance from circulation and the glomerular localization of human serum albumin (HSA) anti-HSA complexes made at fifty-fold antigen excess were examined in mice and compared with the same features of complexes made at five-fold antigen excess. Complexes prepared at fifty-fold antigen excess consisted principally of small-latticed complexes (Ag2Ab2 and Ag1Ab1) that persisted in the circulation after the initial rapid disappearance attributed to extravasation. The presence of small-latticed complexes in the circulation did not lead to glomerular localization of complexes during a 96 hr period. In contrast, when large-latticed soluble complexes, prepared at five-fold antigen excess, were injected, abundant glomerular deposits developed. These observations indicate that the lattice of circulating immune complexes must exceed the Ag2Ab2 structure in order for glomerular deposition to occur.
在小鼠中检测了在抗原过量50倍条件下制备的人血清白蛋白（HSA）-抗HSA复合物从循环中的消失情况及其肾小球定位，并将其与在抗原过量5倍条件下制备的复合物的相同特征进行比较。在抗原过量50倍条件下制备的复合物主要由小网格复合物（Ag2Ab2和Ag1Ab1）组成，在最初因血管外渗导致快速消失后，这些复合物仍存在于循环中。在96小时内，循环中存在的小网格复合物并未导致复合物在肾小球定位。相反，当注射在抗原过量5倍条件下制备的大网格可溶性复合物时，会形成大量肾小球沉积物。这些观察结果表明，为了发生肾小球沉积，循环免疫复合物的网格结构必须超过Ag2Ab2结构。
Zotero 插件