Koransky J S, Roenigk H H
J Am Acad Dermatol. 1982 Aug;7(2):183-9. doi: 10.1016/s0190-9622(82)70106-9.
The concurrence of vitiligo and psoriasis in a single patient has previously been considered unusual. The clustering of seven such patients at our institution over the past 3 years prompted a literature review. Only eighteen well-documented cases could be found, although the incidence of psoriasis in larger series of vitiligo patients seems greater than the isolated case reports would indicate. The occasional tendency of psoriasis to start in, or remain confined to, areas of vitiligo, as well as a purported resistance of dark skin to psoriasis, has tempted some to conclude that depigmented skin may be predisposed to psoriasis. This tendency, however, was not observed in our seven cases or in the majority of previously reported cases. Immunologic phenomena abound in both vitiligo and psoriasis, and the incidence of immunologic phenomena may be increased in patients with both diseases. These phenomena, however, are too dissimilar to draw any conclusions regarding pathogenetic links between vitiligo and psoriasis. The workup of our seven cases, including complete blood cell count and differential, platelet count, VDRL, SMA 18, antinuclear antibodies, thyroid function studies, antithyroid antibodies, urinalysis, eye examination, and skin biopsies, did not further elucidate any possible relationship between vitiligo and psoriasis.
白癜风和银屑病在同一患者中并发，以往被认为不常见。在过去3年里，我院有7例这样的患者聚集，促使我们进行了文献综述。尽管在更大规模的白癜风患者系列中银屑病的发病率似乎高于个别病例报告所显示的，但仅发现18例有充分记录的病例。银屑病偶尔有起始于白癜风区域或局限于白癜风区域的倾向，以及据称深色皮肤对银屑病有抵抗力，这使得一些人得出结论，色素脱失的皮肤可能易患银屑病。然而，在我们的7例病例以及大多数先前报道的病例中并未观察到这种倾向。白癜风和银屑病中都存在大量免疫现象，两种疾病患者的免疫现象发生率可能会增加。然而，这些现象差异太大，无法就白癜风和银屑病之间的发病机制联系得出任何结论。对我们这7例病例的检查，包括全血细胞计数及分类、血小板计数、性病研究实验室玻片试验、18项血清酶类检查、抗核抗体、甲状腺功能检查、抗甲状腺抗体、尿液分析、眼科检查和皮肤活检，并未进一步阐明白癜风和银屑病之间的任何可能关系。
