Drucker C R, Duncan W C
J Am Acad Dermatol. 1982 Sep;7(3):359-63. doi: 10.1016/s0190-9622(82)70123-9.
Seven patients with atrophie blanche or livedo vasculitis of the lower extremities showed abnormal platelet functions in vitro. Six of seven showed hyperaggregation with epinephrine and/or collagen, three showed increased platelet adhesiveness, three showed increased platelet count, and one showed increased microemboli. After treatment with dipyridamole and aspirin, all showed return to normal platelet function. Clinical improvement occurred in all patients, with significant alleviation of pain and decrease in new lesion formation. Although enhanced healing of lesions seemed evident to physician and patient, it was incomplete. In two patients, pain returned when dipyridamole and aspirin were stopped, but the patients improved again when the medicines were restarted. These preliminary findings indicate a possible beneficial effect of antiplatelet therapy in atrophie blanche and livedo vasculitis. A double-blind study is being undertaken to further study this effect.
7例患有下肢白色萎缩或青斑性血管炎的患者在体外显示出血小板功能异常。7例中有6例对肾上腺素和/或胶原表现出高聚集性，3例显示血小板黏附性增加，3例显示血小板计数增加，1例显示微栓子增加。在用双嘧达莫和阿司匹林治疗后，所有患者的血小板功能均恢复正常。所有患者的临床症状均有改善，疼痛明显减轻，新病灶形成减少。尽管医生和患者都明显感觉到病灶愈合加快，但并不完全。有2例患者在停用双嘧达莫和阿司匹林后疼痛复发，但重新用药后症状再次改善。这些初步研究结果表明抗血小板治疗对白色萎缩和青斑性血管炎可能具有有益作用。正在进行一项双盲研究以进一步研究这种作用。
