Luchi R J, Snow E, Luchi J M, Nelson C L, Pircher F J
J Am Geriatr Soc. 1982 Nov;30(11):700-5. doi: 10.1111/j.1532-5415.1982.tb01983.x.
Left ventricular ejection fraction was measured by gated wall motion in 62 patients, 75 years old or older, admitted to a Geriatric Acute Assessment Ward. From this group, 42 patients not taking digitalis or other cardioactive medication were selected for analysis. Thirty of them had clinically identifiable heart disease, whereas 12 did not. Resting left ventricular ejection fractions in the 12 patients without clinically identifiable heart disease averaged 0.60 +/- 0.09. None had an ejection fraction below 0.50. In the 30 patients with clinically identifiable heart disease, mean ejection fraction was 0.49 +/- 0.15 (range 0.17-0.84), P less than 0.01. In the patients with heart disease, reduction of ejection fraction was correlated with either cardiac enlargement or congestive heart failure. Neither age nor electrocardiographic abnormalities added to the strength of this correlation. Fifty-eight per cent of patients with congestive heart failure had ejection fractions greater than or equal to 0.40, suggesting that congestive heart failure in this age group is frequently related to diastolic left ventricular dysfunction unaccompanied by major systolic dysfunction. The prognosis of patients with congestive heart failure and ejection fractions above 0.35 was significantly better than of patients with congestive heart failure and ejection fractions below 0.35. From these data and other data available in the literature, it is proposed that the lower limit for ejection fraction be 0.50 for patients 75 years old or older. Congestive heart failure in patients 75 years old or older appears to be associated with relatively higher ejection fractions or even with ejection fractions within the normal range. In these patients, digitalis may not be indicated, and short term-prognosis is relatively favorable.
对入住老年急性评估病房的62例75岁及以上患者,采用门控心肌运动法测量左心室射血分数。从该组患者中,选取42例未服用洋地黄或其他心脏活性药物的患者进行分析。其中30例有临床可识别的心脏病,12例没有。12例无临床可识别心脏病患者的静息左心室射血分数平均为0.60±0.09。无人射血分数低于0.50。30例有临床可识别心脏病的患者,平均射血分数为0.49±0.15(范围0.17 - 0.84),P<0.01。在有心脏病的患者中,射血分数降低与心脏扩大或充血性心力衰竭相关。年龄和心电图异常均未增强这种相关性。58%的充血性心力衰竭患者射血分数大于或等于0.40,提示该年龄组的充血性心力衰竭常与舒张期左心室功能障碍有关,而无明显收缩期功能障碍。充血性心力衰竭且射血分数高于0.35的患者预后明显好于充血性心力衰竭且射血分数低于0.35的患者。根据这些数据以及文献中的其他数据,建议75岁及以上患者的射血分数下限为0.50。75岁及以上患者的充血性心力衰竭似乎与相对较高的射血分数甚至正常范围内的射血分数有关。在这些患者中,可能不需要使用洋地黄,短期预后相对较好。