Jarvik L F, Mintz J, Steuer J, Gerner R
J Am Geriatr Soc. 1982 Nov;30(11):713-7. doi: 10.1111/j.1532-5415.1982.tb01987.x.
Two concurrent studies of geriatric outpatients who received diagnoses of depression were conducted. In the first, patients were treated with one of two tricyclic antidepressants or with a placebo. In the second, patients were assigned to groups receiving either psychodynamic group therapy or cognitive-behavioral group therapy. Patients in the placebo group showed the least improvement; most patients receiving group psychotherapy showed some improvement, but only 12% had full remissions; by contrast, 45% of patients receiving imipramine or doxepin had full remissions, while 36% of them experienced little or no benefit. An early response to tricyclic antidepressant drugs was a reliable predictor of continued improvement.
针对被诊断患有抑郁症的老年门诊患者进行了两项同期研究。在第一项研究中，患者接受两种三环类抗抑郁药之一或安慰剂治疗。在第二项研究中，患者被分配到接受精神动力学团体治疗或认知行为团体治疗的组中。安慰剂组的患者改善最少；大多数接受团体心理治疗的患者有一定改善，但只有12%完全缓解；相比之下，接受丙咪嗪或多塞平治疗的患者中有45%完全缓解，而其中36%获益很少或没有获益。对三环类抗抑郁药的早期反应是持续改善的可靠预测指标。
