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孕期对小鼠胎盘及血清雄激素、孕酮和催乳素样活性的影响。

Gestational effects on placental and serum androgen, progesterone and prolactin-like activity in the mouse.

作者信息

Soares M J, Talamantes F

出版信息

J Endocrinol. 1982 Oct;95(1):29-36. doi: 10.1677/joe.0.0950029.

DOI:10.1677/joe.0.0950029
PMID:7130889
Abstract

The concentrations of androgen, progesterone and prolactin-like activity in serum, placentae and media from placental incubations during the second half of pregnancy in the C3H mouse were evaluated. Serum concentrations, placental content and in-vitro placental release of androgen were raised on day 10 of pregnancy. Serum progesterone levels showed minor fluctuations during the second half of gestation, whereas placenta content and in-vitro release of progesterone were increased on day 10 of gestation. The serum profile of prolactin-like activity showed a significant mid-pregnancy increase on day 10 which did not correlate with placental content or in-vitro placental release of prolactin-like activity. The placental content and in-vitro release of prolactin-like activity were low during mid-pregnancy and increased during the latter days of gestation when serum prolactin-like activity was reduced.

摘要

对C3H小鼠妊娠后半期血清、胎盘及胎盘孵育培养液中的雄激素、孕酮和催乳素样活性浓度进行了评估。妊娠第10天时,血清雄激素浓度、胎盘雄激素含量及胎盘体外雄激素释放量均升高。妊娠后半期血清孕酮水平有轻微波动,而妊娠第10天时胎盘孕酮含量及胎盘体外孕酮释放量增加。催乳素样活性的血清水平在妊娠第10天出现显著的中期升高,这与胎盘催乳素样活性的含量或胎盘体外释放量无关。妊娠中期胎盘催乳素样活性的含量和体外释放量较低,而在妊娠后期血清催乳素样活性降低时其含量和释放量增加。

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J Endocrinol. 1982 Oct;95(1):29-36. doi: 10.1677/joe.0.0950029.
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