Lavy G, Barnea E R, Decherney A H
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Placenta. 1987 Jul-Aug;8(4):443-8. doi: 10.1016/0143-4004(87)90072-5.
In an attempt to define better the metabolic differences between normal, insulin-dependent and non-insulin-dependent diabetes, we have compared the effect of insulin on the secretion of oestradiol and progesterone in term placental explant culture. Placentae from non-diabetic and from diabetic, non-insulin-dependent diabetic patients demonstrated a similar response to incubation with insulin. This response consisted of a dose-dependent increase in both oestradiol and progesterone in the incubation media after 24 h. In contrast, the placentae of insulin-dependent diabetics showed a decrease in oestradiol and no change in progesterone secretion following exposure to insulin. These differences in response to insulin may underlie other metabolic differences between the placentae in the different groups.
为了更好地界定正常、胰岛素依赖型和非胰岛素依赖型糖尿病之间的代谢差异，我们比较了胰岛素对足月胎盘外植体培养物中雌二醇和孕酮分泌的影响。来自非糖尿病患者以及糖尿病、非胰岛素依赖型糖尿病患者的胎盘对胰岛素孵育表现出相似的反应。这种反应表现为24小时后孵育培养基中雌二醇和孕酮均呈剂量依赖性增加。相比之下，胰岛素依赖型糖尿病患者的胎盘在暴露于胰岛素后，雌二醇分泌减少，孕酮分泌无变化。这些对胰岛素反应的差异可能是不同组胎盘之间其他代谢差异的基础。
