Shirama K, Furuya T, Takeo Y, Shimizu K, Maekawa K
J Endocrinol. 1982 Oct;95(1):87-94. doi: 10.1677/joe.0.0950087.
Pinealectomized and sham-pinealectomized male rats were subcutaneously implanted with 2 cm silicone elastomer capsules filled with testosterone or dihydrotestosterone (DHT) and placed in constant darkness (DD) for 50 days. The data revealed that the sham-pinealectomized group treated with testosterone differed from the pinealectomized group, having lower weights of accessory sexual organs and levator ani muscle. Pinealectomy had no effect on organ and muscle weights of DHT-treated animals. Exposure of male rats to DD resulted in a marked decrease in weights of ventral prostate, seminal vesicle, coagulating gland and levator ani muscle and a decrease in plasma DHT levels. However there was no significant reduction in plasma LH, FSH or testosterone. Pinealectomy of the rats exposed to DD resulted in restoration of both DHT levels and accessory sex organ weights. Melatonin implants in pinealectomized males led to an increase in both testosterone and DHT levels, accompanied by a decrease in sexual organ weights. The data indicate that the anti-gonadal effect of the pineal gland cannot be completely mediated by melatonin and that melatonin and some unknown factors can act at the tissue level to reduce the size and function of the affected sexual organs.
对松果体切除和假松果体切除的雄性大鼠皮下植入装有睾酮或双氢睾酮（DHT）的2厘米硅胶弹性体胶囊，并置于持续黑暗（DD）环境中50天。数据显示，接受睾酮治疗的假松果体切除组与松果体切除组不同，其附属性器官和提肛肌重量较低。松果体切除对接受DHT治疗的动物的器官和肌肉重量没有影响。雄性大鼠暴露于DD环境导致腹侧前列腺、精囊、凝固腺和提肛肌重量显著下降，血浆DHT水平降低。然而，血浆促黄体生成素（LH）、促卵泡生成素（FSH）或睾酮没有显著降低。暴露于DD环境的大鼠进行松果体切除导致DHT水平和附属性器官重量恢复。给松果体切除的雄性大鼠植入褪黑素导致睾酮和DHT水平升高，同时性器官重量下降。数据表明，松果体的抗性腺作用不能完全由褪黑素介导，并且褪黑素和一些未知因素可以在组织水平起作用，以减小受影响性器官的大小并降低其功能。
