膳食蛋白质和脂肪含量对大鼠肝脏中滴滴涕代谢影响的研究。

Studies on the effect of dietary protein and fat content upon DDT metabolism in rat liver.

作者信息

Ando M

出版信息

J Toxicol Environ Health. 1982 Jul;10(1):11-22. doi: 10.1080/15287398209530226.

DOI:10.1080/15287398209530226

Abstract

Rats were supplied with 25 kinds of food, which were divided into 5 classes of protein and 5 classes of fat content, to examine the effect of dietary protein and fat on the metabolism and retention of DDT in the liver. The results suggested that dietary protein and fat changed DDT and its metabolites concentration in liver. The concentration of DDT decreases according to the increase of dietary protein content. The concentration of DDT and its metabolites in liver increases when the dietary fat content increases. Polynomial and multiple regression analyses were carried out to confirm the effect of dietary protein and fat on DDT metabolism. The results suggest that the residual concentration of DDT and its metabolites (DDD and DDE) is a function of dietary protein and fat content, and can be represented in equation form. The estimation of the concentration of DDT and its metabolites from the equation agrees well with the measured concentration in liver.

摘要

给大鼠提供25种食物，这些食物分为5类蛋白质和5类脂肪含量，以研究膳食蛋白质和脂肪对肝脏中滴滴涕代谢和潴留的影响。结果表明，膳食蛋白质和脂肪改变了肝脏中滴滴涕及其代谢物的浓度。滴滴涕的浓度随着膳食蛋白质含量的增加而降低。当膳食脂肪含量增加时，肝脏中滴滴涕及其代谢物的浓度会升高。进行了多项式和多元回归分析以确认膳食蛋白质和脂肪对滴滴涕代谢的影响。结果表明，滴滴涕及其代谢物（滴滴滴和滴滴伊）的残留浓度是膳食蛋白质和脂肪含量的函数，并且可以用方程形式表示。根据该方程估算的滴滴涕及其代谢物的浓度与肝脏中测得的浓度非常吻合。