Owen D A, Harvey C A, Boyce M J
Klin Wochenschr. 1982 Sep 1;60(17):972-7. doi: 10.1007/BF01716957.
Experiments have been made in anaesthetised cats and dogs and in healthy, human volunteers to compare the changes in blood pressure and heart rate during systemic administration of histamine. Histamine, 1 x 10(-9) to 1 x 10(-7) mol/kg/min, lowered blood pressure in a similar dose-dependent fashion in all three species. In man and the cat this was accompanied by clear dose-dependent tachycardia whereas in the dog heart rate changes were minimal. Pharmacological analysis of the depressor responses to histamine in all three species and the reduction in total peripheral resistance in the cat and dog showed that the immediate responses to histamine in all three species involved H1-receptors and that sustained responses involved H2-receptors. Abolition of responses to histamine throughout infusions required H1-and H2-receptor blockade. Histamine antagonists, used in doses which cause abolition of cardiovascular responses to large doses of histamine, do not cause any significant change in the resting cardiovascular system.
已在麻醉的猫和狗以及健康的人类志愿者身上进行实验，以比较全身给予组胺期间血压和心率的变化。组胺剂量为1×10⁻⁹至1×10⁻⁷摩尔/千克/分钟时，在所有这三个物种中均以类似的剂量依赖性方式降低血压。在人和猫中，这伴随着明显的剂量依赖性心动过速，而在狗中，心率变化最小。对所有这三个物种中组胺降压反应以及猫和狗总外周阻力降低的药理学分析表明，所有这三个物种对组胺的即时反应涉及H1受体，而持续反应涉及H2受体。在整个输注过程中消除对组胺的反应需要同时阻断H1和H2受体。组胺拮抗剂以能消除对大剂量组胺心血管反应的剂量使用时，不会使静息心血管系统发生任何显著变化。
