Gurtner J, Vorburger C, Reubi F
Klin Wochenschr. 1978 Sep 1;56(17):865-71. doi: 10.1007/BF01479837.
In 111 Patients with a wide range of renal function (normal to advanced renal failure) the renal clearances of Na-paraaminohippurate (CPAH) and of Na-orthojodohippurate--J125(COJ(J125(H) have been simultaneously determined under standardized clearance conditions. We found a significant correlation between the 2 parameters, defined by the equation CPAH = 1.11.COJ(J125)H. The scatter of the single observations however is considerable and hence the +/- 2Sy range is very large. The difference between the 2 clearances is not die to a competition at the same tubular carrier, since adding inactive carrier of OJH does not improve the ratio of the 2 clearances: CPAH = 1.13.COJ(J125)H. Rather the renal extraction of OJ(J125)H(EOJ(J125)H is considerably lower (74% than EPAH (90%). Our datas suggest that OJ(J125)H is not a suitable indicator to replace PAH for measurements of real renal plasma flow.
在111名肾功能范围广泛（从正常到晚期肾衰竭）的患者中，在标准化清除条件下同时测定了对氨基马尿酸钠（CPAH）和邻碘马尿酸钠——J125（COJ（J125（H）的肾清除率。我们发现这两个参数之间存在显著相关性，由方程CPAH = 1.11.COJ（J125）H定义。然而，单个观测值的离散度相当大，因此±2Sy范围非常大。这两种清除率之间的差异并非由于在同一肾小管载体上的竞争，因为添加无活性的OJH载体并不能改善这两种清除率的比值：CPAH = 1.13.COJ（J125）H。相反，邻碘马尿酸钠——J125（OJ（J125）H的肾提取率（EOJ（J125）H）明显低于对氨基马尿酸（PAH）的肾提取率（EPAH）（74%对比90%）。我们的数据表明，邻碘马尿酸钠——J125（OJ（J125）H不是替代对氨基马尿酸（PAH）用于测量实际肾血浆流量的合适指标。
