Kuprys R, Oltmans G A
Pharmacol Biochem Behav. 1982 Aug;17(2):271-82. doi: 10.1016/0091-3057(82)90081-8.
Genetically obese mice (obob) and their lean littermates were acclimated to a restricted food-access schedule of six hours and then treated with various doses of amphetamine (0, 3, 5 or 10 mg/kg). Saline-treated obob mice maintained on this schedule retained the primary characteristics of obob mice fed ad lib, i.e., hyperphagia, hyperglycemia, elevated hypothalamic norepinephrine (NE) levels. Both lean and obese mice treated with amphetamine showed a dose-dependent decrease in food intake and hypothalamic NE levels. In obob mice amphetamine treatment reduced food intake and hypothalamic NE levels to values which were not significantly different from those of similarly treated lean mice. When the drug dose was administered on a body weight basis, however, brain amphetamine levels were twice as high in obob as in lean mice. When the amphetamine dose was adjusted to produce approximately equivalent brain levels of amphetamine in obob and lean mice, the obob mice ate significantly more than lean mice. The results indicate that amphetamine is an effective anorectic agent capable of reducing food intake, body weight, and hypothalamic NE levels in obob mice.
遗传性肥胖小鼠（obob）及其瘦的同窝小鼠适应了6小时的限制进食时间表，然后用不同剂量的苯丙胺（0、3、5或10毫克/千克）进行处理。按此时间表用生理盐水处理的obob小鼠保留了自由进食的obob小鼠的主要特征，即食欲亢进、高血糖、下丘脑去甲肾上腺素（NE）水平升高。用苯丙胺处理的瘦小鼠和肥胖小鼠的食物摄入量和下丘脑NE水平均呈剂量依赖性下降。在obob小鼠中，苯丙胺处理使食物摄入量和下丘脑NE水平降低到与同样处理的瘦小鼠无显著差异的值。然而，当按体重给药时，obob小鼠脑中的苯丙胺水平是瘦小鼠的两倍。当调整苯丙胺剂量以使obob小鼠和瘦小鼠脑中的苯丙胺水平大致相当时，obob小鼠的食量明显大于瘦小鼠。结果表明，苯丙胺是一种有效的食欲抑制剂，能够降低obob小鼠的食物摄入量、体重和下丘脑NE水平。
