Oltmans G A, Lorden J F, Margules D L
Pharmacol Biochem Behav. 1976 Dec;5(6):617-20. doi: 10.1016/0091-3057(76)90301-4.
Norepinephrine (NE) levels in the hypothalamus and telencephalon of genetically obese mice with the OBOB and DBDB mutations are significantly higher than those of their lean littermates. Obese mice with the viable yellow mutation failed to show this increase. Restricting the diets of OBOB animals to prevent excessive weight gain does not affect NE levels in the hypothalamus, telencephalon or brainstem.
携带OBOB和DBDB突变的遗传性肥胖小鼠下丘脑和端脑中的去甲肾上腺素(NE)水平显著高于其瘦型同窝小鼠。携带可行黄色突变的肥胖小鼠未出现这种升高。限制OBOB动物的饮食以防止体重过度增加,并不会影响下丘脑、端脑或脑干中的NE水平。