Treit D, Pinel J P, Fibiger H C
Pharmacol Biochem Behav. 1982 Aug;17(2):359-61. doi: 10.1016/0091-3057(82)90092-2.
The ability of picrotoxin to reverse the effect of diazepam was studied using the conditioned defensive burying paradigm. Although picrotoxin alone had no detectable effect on the conditioned defensive burying response of rats, picrotoxin was able to reverse the usual inhibitory effect of diazepam on defensive burying. These results suggest that the anxiolytic effect of diazepam may depend upon the integrity of GABAergic neural systems.
使用条件性防御性埋埋范式研究了印防己毒素逆转地西泮作用的能力。尽管单独使用印防己毒素对大鼠的条件性防御性埋埋反应没有可检测到的影响，但印防己毒素能够逆转地西泮通常对防御性埋埋的抑制作用。这些结果表明，地西泮的抗焦虑作用可能取决于GABA能神经系统的完整性。
