Esquivel C O, Bergqvist D, Björck C G, Carson S N, Nilsson B
Thromb Haemost. 1982 Aug 24;48(1):87-90.
The effect of sodium ibuprofen on platelet activity in vivo and the lysability of ex vivo thrombi was investigated. The formation of a hemostatic platelet plug in the rabbit mesentery and platelet embolism as a response to a laser-induced injury in the ear chamber of rabbits were used as models for determining platelet activity. Ibuprofen at a dose of 25 mg/kg i.v. was found to increase the primary (PHT) and the total hemostatic plug formation time (THT). The same dose decreased the number of cumulative emboli over a 10 min period after a laser injury to arterioles. A dose of 10 mg/kg i.v. did not affect the formation of the hemostatic platelet plug. In dogs, doses of 10, 25 und 50 mg/kg did not enhance the release of 125I-FDP from the thrombi after incubation in plasmin, but the largest dose which is approximately five times the recommended dose in humans, did significantly decrease the thrombus weight 90 and 180 min after the drug administration. In conclusion, sodium ibuprofen was shown to have an inhibitory effect on platelet function in vivo and in large doses was also found to diminish the thrombus weight.
研究了布洛芬钠对体内血小板活性和体外血栓溶解性的影响。以兔肠系膜中止血性血小板栓子的形成以及兔耳室激光诱导损伤后血小板栓塞作为测定血小板活性的模型。静脉注射剂量为25mg/kg的布洛芬可延长初级止血时间（PHT）和总止血栓形成时间（THT）。相同剂量可减少激光损伤小动脉后10分钟内累积栓子的数量。静脉注射剂量为10mg/kg时不影响止血性血小板栓子的形成。在犬体内，剂量为10、25和50mg/kg时，在纤溶酶中孵育后不会增强血栓中125I-FDP的释放，但最大剂量（约为人类推荐剂量的五倍）在给药后90分钟和180分钟时可显著降低血栓重量。总之，布洛芬钠在体内对血小板功能具有抑制作用，大剂量时还可减轻血栓重量。
